Organic Chemistry

Home - Products - Organic Chemistry

3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid

  • Product Name: 3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid
  • CasNo: 500011-86-9
  • Purity:
  • Appearance:

Mobile/Wechat/WhatsApp: +86 18892628267

Email:libbywu@fellowchemical.com

Inquiry

CasNo: 500011-86-9

Molecular Formula: C9H5BrClN3O2

Factory Supply 500011-86-9 with Competitive Price, Buy Reliable Quality 3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid

  • Molecular Formula:C9H5BrClN3O2
  • Molecular Weight:302.515
  • Vapor Pressure:0Pa at 20℃ 
  • Melting Point:197-200 °C 
  • Boiling Point:477.4±45.0 °C(Predicted) 
  • PKA:2.39±0.36(Predicted) 
  • PSA:68.01000 
  • Density:1.92±0.1 g/cm3(Predicted) 
  • LogP:2.38140 

500011-86-9 usage

3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid is an organic compound that features a complex structure with multiple functional groups. It contains a pyrazole ring, a five-membered aromatic heterocycle with nitrogen atoms at the 1 and 2 positions, which is substituted with a bromine atom at the 3 position and a carboxylic acid group at the 5 position. Additionally, this pyrazole ring is linked to a 3-chloropyridine moiety, which is a six-membered aromatic ring with nitrogen at the 2 position and a chlorine atom at the 3 position. This compound likely has interesting chemical properties due to the presence of both electron-donating and electron-withdrawing groups, making it potentially useful in various chemical reactions and applications, particularly in the field of medicinal chemistry where such heterocyclic structures are common in bioactive molecules.

500011-86-9 Relevant articles

Design, synthesis and insecticidal-activity evaluation of N-pyridylpyrazolo-5-methyl amines and its derivatives

Yang, Shuai,Xu, Kaijie,Lai, Qiuqin,Zhao, Chen,Xu, Hanhong

, p. 4304 - 4311 (2020)

In searching for novel insecticidal lead...

PROCESS FOR PREPARATION OF SUBSTITUTED PYRAZOLES

-

Page/Page column 18-20, (2022/03/09)

: The present invention relates to the p...

METHODS FOR THE PREPARATION OF 5-BROMO-2-(3-CHLORO-PYRIDIN-2-YL)-2H-PYRAZOLE-3-CARBOXYLIC ACID

-

Paragraph 0256; 0257, (2021/04/23)

Described herein are novel methods of sy...

METHODS FOR THE PREPARATION OF 5-BROMO-2-(3-CHLORO-PYRIDIN-2-YL)-2H-PYRAZOLE-3-CARBOXYLIC ACID

-

Paragraph 0202; 0203, (2021/04/23)

Described herein are novel methods of sy...

METHODS FOR THE PREPARATION OF 5-BROMO-2-(3-CHLORO-PYRIDIN-2-YL)-2H-PYRAZOLE-3-CARBOXYLIC ACID

-

Paragraph 0299-0308, (2021/04/23)

Described herein are novel methods of sy...

500011-86-9 Process route

3-bromo-1-(3-chloropyridine-2-yl)-1H-pyrazole-5-carboxylic acid methyl ester
1045077-26-6

3-bromo-1-(3-chloropyridine-2-yl)-1H-pyrazole-5-carboxylic acid methyl ester

3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid
500011-86-9

3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid

Conditions
Conditions Yield
With sodium hydroxide; In toluene; at 80 - 85 ℃; for 2h;
97%
 
 
With sodium hydroxide; In water; at 80 ℃; for 2h; Inert atmosphere;
 
With methanol; sodium hydroxide; at 20 ℃; for 1h;
 
With sodium hydroxide; In toluene; at 80 - 85 ℃;
 
With sodium hydroxide; In toluene; at 80 - 85 ℃; for 2h;
 
With sodium hydroxide; In toluene; at 60 ℃; for 3h;
16.1 g
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine
500011-85-8

2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine

carbon dioxide
124-38-9,18923-20-1

carbon dioxide

3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid
500011-86-9

3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid

Conditions
Conditions Yield
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With methylmagnesium bromide; diisopropylamine; In tetrahydrofuran; at 0 ℃; for 2.5h;
carbon dioxide; at 20 ℃; for 1h;
95%
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;
carbon dioxide; In tetrahydrofuran; Further stages.;
87%
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;
carbon dioxide; In tetrahydrofuran; at -78 - -20 ℃;
59%
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -76 - -71 ℃; for 0.25h;
carbon dioxide; In tetrahydrofuran; at -76 - -57 ℃; for 0.166667h;
 
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -76 - -71 ℃; for 0.25h;
carbon dioxide; In tetrahydrofuran; at -57 ℃; for 0.166667h;
With hydrogenchloride; In water;
 
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -76 ℃; for 0.25h;
carbon dioxide; In tetrahydrofuran; at -76 - -57 ℃; for 0.166667h;
 
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃;
carbon dioxide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 - 20 ℃; for 1h;
With water; sodium hydroxide; In tetrahydrofuran; n-heptane; ethylbenzene; at 20 ℃; pH=10 - 12;
 
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -76 ℃; for 0.25h;
carbon dioxide; In tetrahydrofuran; at -76 - -57 ℃; for 0.166667h;
 
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -76 - -71 ℃; for 0.25h;
carbon dioxide; In tetrahydrofuran; at -76 - -57 ℃; for 0.166667h;
27.7 g
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at 76 ℃; for 0.25h;
carbon dioxide; at 20 - 57 ℃;
27.7 g
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With methylmagnesium chloride; diisopropylamine; In tetrahydrofuran; at 0 ℃; for 2.5h;
carbon dioxide; In tetrahydrofuran; at 20 - 40 ℃;
30 g
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With methylmagnesium chloride; diisopropylamine; lithium chloride; In tetrahydrofuran; toluene; at 5 - 15 ℃; for 6.75h;
carbon dioxide; In tetrahydrofuran; toluene; for 0.25h; Reagent/catalyst; Temperature; Solvent;
46 g

500011-86-9 Upstream products

  • 500011-85-8
    500011-85-8

    2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine

  • 124-38-9
    124-38-9

    carbon dioxide

  • 500011-92-7
    500011-92-7

    5-bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazole-3-carboxylic acid ethyl ester

  • 1045077-26-6
    1045077-26-6

    3-bromo-1-(3-chloropyridine-2-yl)-1H-pyrazole-5-carboxylic acid methyl ester

500011-86-9 Downstream products

  • 736995-63-4
    736995-63-4

    2-[1-(3-chloropyridine-2-yl)-3-bromo-1H-pyrazole-5-yl]-6-iodo-8-methyl-4H-3,1-benzoxazine-4-one

  • 500008-45-7
    500008-45-7

    rynaxypyr

  • 736994-63-1
    736994-63-1

    cyantraniliprole

  • 1072138-15-8
    1072138-15-8

    C22H18Br3ClN6O4

Leave Your Message

Relevant Products