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4-AminobenzamidineDihydrochloride

  • Product Name: 4-AminobenzamidineDihydrochloride
  • CasNo: 2498-50-2
  • Purity:
  • Appearance: white to yellowish fine crystalline powder

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CasNo: 2498-50-2

Molecular Formula: C7H11Cl2N3

Appearance: white to yellowish fine crystalline powder

Buy High Quality Quality Factory Supply 4-AminobenzamidineDihydrochloride 2498-50-2 with the Best Price

  • Molecular Formula:C7H11Cl2N3
  • Molecular Weight:208.09
  • Appearance/Colour:white to yellowish fine crystalline powder 
  • Vapor Pressure:0.00216mmHg at 25°C 
  • Melting Point:>300 °C(lit.) 
  • Boiling Point:289.8 °C at 760 mmHg 
  • Flash Point:129 °C 
  • PSA:75.89000 
  • Density:1.26g/cm3 
  • LogP:3.53810 

4-Aminobenzamidine dihydrochloride(Cas 2498-50-2) Usage

Preparation

4-Aminobenzamididine dihydrochloride is obtained by cyanation, addition, amination and reduction of 4-nitrobenzoic acid.

Application

4-Aminobenzamidine dihydrochloride can be used to synthesize:Orally active fibrinogen receptor antagonists based on benzamidines.Benzamidine derivatives that are selective and potent serine protease inhibitors.Novel pyrrolo [3,2-c] quinolines that are structural analogs of topoisomerase inhibitors such as coralyne and fagaronine.Synthesis of a selective inhibitor of PRMT1 (SKLB-639)

InChI:InChI=1/C7H9N3/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H3,9,10)/p+1

2498-50-2 Relevant articles

Novel preparation method of p-aminobenzamidine hydrochloride

-

Paragraph 0032; 0033; 0035; 0037; 0039; 0041; 0043; 0045, (2018/11/22)

The invention discloses a novel preparat...

Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform

Pant, Shishir M.,Mukonoweshuro, Amanda,Desai, Bimbisar,Ramjee, Manoj K.,Selway, Christopher N.,Tarver, Gary J.,Wright, Adrian G.,Birchall, Kristian,Chapman, Timothy M.,Tervonen, Topi A.,Klefstr?m, Juha

supporting information, p. 4335 - 4347 (2018/05/14)

Hepsin is a membrane-anchored serine pro...

A to prepare to aminobenzoic amidine hydrochloride method

-

, (2017/02/02)

The invention relates to the technical f...

Design, synthesis and structure-activity relationships of novel diaryl urea derivatives as potential EGFR inhibitors

Jiang, Nan,Bu, Yanxin,Wang, Yu,Nie, Minhua,Zhang, Dajun,Zhai, Xin

, (2016/12/03)

Two novel series of diaryl urea derivati...

2498-50-2 Process route

4-nitrobenzamidine
25412-75-3

4-nitrobenzamidine

4-aminobenzamidine dihydrochloride
2498-50-2

4-aminobenzamidine dihydrochloride

Conditions
Conditions Yield
4-nitrobenzamidine; With iron; acetic acid; In ethanol; water; at 60 - 80 ℃; for 4h;
With hydrogenchloride; In ethanol; water; Reagent/catalyst;
94.7%
N-(4-cyanophenyl)acetamide
35704-19-9

N-(4-cyanophenyl)acetamide

4-aminobenzamidine dihydrochloride
2498-50-2

4-aminobenzamidine dihydrochloride

Conditions
Conditions Yield
N-(4-cyanophenyl)acetamide; With sodium amide; In dimethyl sulfoxide; at 20 - 80 ℃; for 1.5h; Large scale;
With hydrogenchloride; In ethanol; dimethyl sulfoxide; at 0 ℃; for 1.5h; pH=3 - 4; Solvent; Reagent/catalyst; Temperature; Large scale;
97.8%

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